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. 1999 Dec 21;96(26):15103–15108. doi: 10.1073/pnas.96.26.15103

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Copyright © 1999, The National Academy of Sciences

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Kaplan–Meier analysis of APML disease in transgenic animals. One PR founder (135) was bred with two independently derived RP founders (2544 and 2683) to establish intercross cohorts. Animals were scored for development of APML (using criteria described previously; see ref. 3) when sacrificed or autopsied. Data represent the complete study of the first intercross (PR 135 × RP1 2544). The cumulative probability of death resulting from APML at 24 months is significantly higher in the PR/RP animals compared with the PR animals (P = 0.0005).