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PR/RP leukemic spleen cells cause death in syngeneic recipients more quickly than PR cells. Each of three independent PR and PR/RP APML tumors were transferred into 20–22 C3H×BL/6 F1 recipients at 1–3 × 106 cells per mouse. Animals were scored for APML on the day of sacrifice or at autopsy, and outcomes were plotted by using a Kaplan–Meier analysis. The difference between the time of death caused by PR vs. PR/RP leukemic spleen cells was highly significant (P < 0.001).
