Table 3.

Rate constants for CD4⁺ T Cell dynamics after stopping and reinitiating therapy

	−kT4 (day−1)	cT4 (day−1)	kBT4 (percent day−1)	−cBT4 (percent day−1)	kBT8 (percent day−1)	−cBT8 (percent day−1)
Mean (±s.d.)	0.015 (±0.011)	0.026 (±0.016)	0.018 (±0.015)	0.020 (±0.016)	0.047 (±0.039)	0.043 (±0.048)

−kT4 and cT4 are the mean rate constants for changes in CD4⁺ T cells after stopping therapy and on restarting drug treatment, respectively. Linear equations were used for fitting the data for the percentage of BrdUrd-labeled CD4⁺ or CD8⁺ T cells (percent BrdUrd-CD4 or percent BrdUrd-CD8 cells, respectively): percent BrdUrd-CD4 = kBT4⋅t + const1, where kBT4 is the respective constant and const1 does not depend on time. For CD8 cells, the constant is kBT8. The same equation was used for fitting the data after resuming therapy but with constants cBT4 and cBT8 for CD4 and CD8 cells, respectively.