Figure 3.

Regional distribution of PrP^Sc in the brains of Tg(BoPrP) mice inoculated with BSE prions. The neuroanatomic distribution of protease-resistant PrP^Sc was virtually identical in Tg(BoPrP)Prnp^0/0 mice inoculated with BSE (C and D) and nvCJD (E and F) prions but different from that found in mice inoculated with sheep scrapie (Sc) prions (A and B). The distribution of PrP^Sc correlates well with the vacuolation scores in Fig. 1. A, C, and E are coronal sections of the cerebral hemispheres at the level of the thalamus and hippocampus. B, D, and F are coronal sections through the pons and cerebellum. Am, amygdala; GC, granule cell layer of cerebellar cortex; Hb, habenula; Hp, hippocampus; Hy, hypothalamus; IC, internal capsule; NC, neocortex; N7, facial nerve; Py, pyramidal tract; S5, spinal tract of trigeminal nerve; Th, thalamus; ZI, zona incerta.