Table 1.
Susceptibility of transgenic mice to BSE, nvCJD, and sheep scrapie prions
| Original source | Inoculum | Incubation time, days (n/n0) |
|---|---|---|
| BSE | PG31/90 | 234 ± 8.3 (10/10) |
| BSE | PG31/90 → Tg(BoPrP)E4125 | 217 ± 6.1 (15/15) |
| BSE | GJ248/85 | 265 ± 22.6 (8/8) |
| BSE | GJ248/85 → Tg(BoPrP)E4125 | 257 ± 6.6 (15/15) |
| BSE | SE1809/11 | 254 ± 6.7 (9/9) |
| BSE | 97/1612 | 220 ± 7.8 (10/10) |
| BSE | 97/1997 | 227 ± 5.4 (5/6) |
| nvCJD | RU96/02 | 271 ± 6.1 (5/6) |
| nvCJD | RU96/07 | 274 ± 5.8 (10/10) |
| nvCJD | RU96/110 | 247 ± 4.3 (8/8) |
| Suffolk sheep scrapie | Ewe 15 | 234 ± 55.4 (3/7) |
| Suffolk sheep scrapie | Ram 139 | 215 ± 7.3 (8/8) |
| Suffolk sheep scrapie | Ewe 340 | 206 ± 5.5 (8/8) |
| Suffolk sheep scrapie | Oreo | 203 ± 5.4 (6/10) |
| Suffolk sheep scrapie | T97-1437 | 245 ± 15.9 (4/5) |
| BSE | PG31/90 → FVB | >540 (0/10) |
Incubation times are presented as mean ± SEM for Tg(BoPrP)4125/Prnp0/0 mice. The numbers in parentheses are the ratio of animals scored sick expressed as a fraction of the total animals.