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Experimental Diabesity Research logoLink to Experimental Diabesity Research
. 2004;5(1):25–36. doi: 10.1080/15438600490424497

The C-peptide Signaling

George Grunberger 1,3, Anders A F Sima 2
PMCID: PMC2478625  PMID: 15198369

Abstract

For years an assumption was made that C-peptide, a byproduct of insulin biosynthesis, possessed no appreciable physiologic role. As other contributions in this volume amply testify, the time has come to re-evaluate that notion. C-peptide either directly through interaction with its specific cell-surface receptor or indirectly through an interaction with a related membrane entity, exerts a unique effect on several intracellular processes.We review here results of studies attempting to elucidate such molecular effects of C-peptide in different cell systems and tissues. Lacking a purified C-peptide receptor, we also demonstrate C-peptide effects on distinct elements of the insulin signal transduction pathways.

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