Figure 5.

Fibrin deficiency does not rescue the lesion of Plg^o livers. Liver sections show a similar centrilobular injury regardless of the genotype 2 days after CCl₄. On day 14, histology of Plg⁺/Fib⁺ and Fib^o livers is normal, whereas the lesion persists in Plg^o and Plg^o/Fib^o livers. (Bottom) Immunohistochemical staining shows the characteristic accumulation of fibrin in diseased Plg^o livers 14 days after CCl₄, whereas no specific staining is noted in diseased Plg^o/Fib^o livers. (Arrowheads, portal vein; arrows, centrilobular region; magnification: ×200.)