Figure 1. Schematic diagram of the Xin repeat alignment.

The conserved Xin repeat unit is represented as a square for the 40 Xin proteins and this conserved Xin repeat region (from aa#89–742 of mXinα and aa#308–1306 of mXinβ) was used as proxies for the complete Xin sequences in this diagram [3]. The consensus Xin repreat region is comprised of 31 Xin repeat units. Large Xin repeat sequence gaps are represented as spaces in the alignment, while solid lines represent amino acids not part of a Xin repeat. The β-catenin binding domain indicated by a grey rectangle is located from the 17^th to the 19^th Xin repeat within the consensus diagram [9]. Species: Hs, Homo sapien (human); Pt, Pan troglodytes (chimpanzee); Mam, Macaca mulatta (rhesus monkey); Cf, Canis lupus familiaris (dog); Ec, Equus caballus (horse); Bt, Bos taurus (cow); Mm, Mus musculus (mouse); Rn, Rattus norvegicus (rat); Md, Monodelphis domestica (opossum); Gg, Gallus gallus (chicken); Ac, Anolis carolinensis (green anole); Xt, Xenopus tropicalis (western clawed frog); Tn, Tetraodon nigroviridis (freshwater pufferfish); Tr, Takifugu rubripes (Japanese pufferfish); Ga, Gasterosteus aculeatus (stickleback); Ol, Oryzias latipes (Japanese medaka); Dr, Danio rerio (zebrafish); Pm, Petromyzon marinus (lamprey).