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. 2008 Aug 6;3(8):e2883. doi: 10.1371/journal.pone.0002883

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Vinci et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A way to show a structural relationship is to predict the hydrophobic profiles of the relevant proteins. Here we have used the TopPred program [36] as implemented in the server of Pasteur Institute (http://www.pasteur.fr). Left panels show the results for the potential homologs of ERG2p while the right panels display the profiles for ERG28p homologs (using the Kyte-Doolitle scale, with the default parameters). Negative (positive) values represent hydrophobic (hydrophilic) segments. A way to statistically assess the similarity of two profiles is to calculate their correlation coefficient R. R-values for pairwise comparisons with the human sequence are reported. We tried to maximize the R-value by slightly sliding one profile over the other (that is why the frames of the profiles are not perfectly aligned).