TABLE 1.
Control | IFN-γ | TNF-α | IL-1β | MCP-1 | MIP-1α | RANTES | |
---|---|---|---|---|---|---|---|
Retina | |||||||
ZO-1 | 17.13 ± 5.65 | 13.01 ± 3.82 | 17.75 ± 5.51 | 14.75 ± 6.59 | 11.70 ± 4.85 | 22.76 ± 8.74 | 18.52 ± 6.48 |
Occludin-1 | 55.42 ± 12.73 | 64.92 ± 11.05 | 58.10 ± 13.59 | 51.29 ± 11.57 | 53.57 ± 6.47 | 38.06 ± 8.22 | 52.21 ± 13.06 |
Claudin-1 | 16.25 ± 5.72 | 11.33 ± 4.16 | 10.71 ± 1.72 | 11.64 ± 6.01 | 13.92 ± 4.96 | 16.48 ± 3.94 | 20.11 ± 6.53 |
Claudin-3 | 67.17 ± 5.15 | 63.32 ± 2.89 | 68.22 ± 11.60 | 49.53 ± 6.45 | 73.18 ± 15.57 | 73.60 ± 10.63 | 70.18 ± 9.87 |
RPE cells | |||||||
ZO-1 | 33.39 ± 4.32 | 31.84 ± 2.76 | 28.04 ± 3.99 | 18.02 ± 2.83* | 18.57 ± 2.41* | 27.37 ± 5.60 | 26.38 ± 7.51 |
Occludin-1 | 28.82 ± 17.93 | 24.50 ± 11.21 | 20.28 ± 10.05 | 14.37 ± 6.17 | 16.49 ± 5.85 | 19.19 ± 5.37 | 24.32 ± 8.23 |
Claudin-1 | 50.75 ± 6.73 | 36.16 ± 17.38 | 47.84 ± 20.33 | 39.21 ± 8.59 | 58.97 ± 12.00 | 53.55 ± 6.58 | 51.10 ± 3.92 |
Claudin-3 | 20.09 ± 9.95 | 10.16 ± 3.51 | 12.75 ± 2.85 | 18.41 ± 4.06 | 17.90 ± 9.23 | 23.13 ± 11.45 | 15.65 ± 5.95 |
P < 0.05 compared with the control group of the same protein. Dunnett multiple comparison test.
Data are expressed as the mean ± SEM (n = 3 × 103).