Table 2.
Differentially expressed cytokines and signaling molecules
| Genes up-regulated in the rejection model | Genes down-regulated in the rejection model | ||||||
|---|---|---|---|---|---|---|---|
| Symbol | Description | reject | contr. | Symbol | Description | reject | contr. |
| Interleukins and receptors | |||||||
| Il1a | interleukin 1 alpha | 2.71 | 0.81 | ||||
| Il1b | interleukin 1 beta | 8.91 | 0.54 | ||||
| Il1f9 | interleukin 1 family, member 9 | 1.97 | 0.82 | ||||
| Il5 | interleukin 5 | 1.64 | 0.87 | ||||
| Il7 | interleukin 7 | 3.11 | 0.84 | ||||
| Il17f | interleukin 17F | 3.86 | 0.68 | ||||
| Il31 | interleukin 31 | 2.16 | 0.80 | ||||
| 1.00 | 1.00 | ||||||
| Il1rap | interleukin 1 receptor accessory protein, transcript variant 2 | 3.56 | 0.70 | ||||
| Il2rg | interleukin 2 receptor, gamma chain | 1.75 | 0.85 | ||||
| Il7r | interleukin 7 receptor | 2.46 | 0.88 | ||||
| Il23r | interleukin 23 receptor | 7.38 | 0.63 | ||||
| Il17rb | interleukin 17 receptor B | 4.46 | 0.65 | ||||
| 1.00 | 1.00 | ||||||
| Cytotoxic and pro-apoptotic molecules | 1.00 | 1.00 | |||||
| Gzmb | granzyme B | 1.90 | 0.83 | ||||
| Gzmb | granzyme B | 1.57 | 0.88 | ||||
| Ctla2a | cytotoxic T lymphocyte-associated protein 2 alpha | 3.60 | 0.69 | ||||
| Klra9 | killer cell lectin-like receptor subfamily A, member 9 | 1.95 | 0.87 | ||||
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 7.36 | 0.57 | ||||
| Fasl | Fas ligand (TNF superfamily, member 6) | 2.78 | 0.75 | Tnfaip1 | tumor necrosis factor, alpha-induced protein 1 | 0.51 | 1.21 |
| Tnfsf11 | tumor necrosis factor (ligand) superfamily, member 11 | 2.56 | 0.80 | ||||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 2.21 | 0.83 | Tnfrsf12a | tumor necrosis factor receptor superfamily, member 12a | 0.14 | 1.52 |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 2.77 | 0.73 | Ngfrap1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.38 | 1.15 |
| Toll-like receptors and lymphocyte signaling | |||||||
| Tlr4 | toll-like receptor 4 | 2.14 | 0.80 | ||||
| Tlr6 | toll-like receptor 6 | 2.98 | 0.86 | ||||
| Il4i1 | interleukin 4 induced 1 | 3.34 | 0.77 | ||||
| Alcam | activated leukocyte cell adhesion molecule | 2.12 | 0.81 | ||||
| Bcl2a1c | B-cell leukemia/lymphoma 2 related protein A1c | 3.41 | 0.70 | ||||
| Itk | IL2-inducible T-cell kinase | 2.63 | 0.76 | Ilf3 | interleukin enhancer binding factor 3, transcript variant 2 | 0.44 | 1.27 |
| Ebf4 | early B-cell factor 4 | 6.32 | 0.75 | ||||
| Ly6a | lymphocyte antigen 6 complex, locus A | 2.83 | 0.74 | ||||
| Ly6c | lymphocyte antigen 6 complex, locus C | 3.18 | 0.72 | Ly6e | Lymphocyte antigen 6 complex, locus E | 0.22 | 1.53 |
| Ly6f | Lymphocyte antigen 6 complex, locus F | 3.62 | 0.67 | Ly6e | lymphocyte antigen 6 complex, locus E | 0.47 | 1.18 |
| Ly6f | lymphocyte antigen 6 complex, locus F | 2.41 | 0.78 | Btla | B and T lymphocyte associated, transcript variant 2 | 0.38 | 1.32 |
| Lck | lymphocyte protein tyrosine kinase | 2.26 | 0.79 | Bcap31 | B-cell receptor-associated protein 31 | 0.34 | 1.36 |
| Tagap | T-cell activation Rho GTPase-activating protein | 2.36 | 0.78 | Tiam2 | T-cell lymphoma invasion and metastasis 2 | 0.47 | 1.24 |
| Tlx1 | T-cell leukemia, homeobox 1 | 7.36 | 0.65 | Ikbkap | inhibitor of kappa light polypeptide enhancer in B-cells | 0.44 | 1.27 |
| Tcl1b1 | T-cell leukemia/lymphoma 1B, 1 | 2.37 | 0.78 | ||||
| Nkrf | NF-kappaB repressing factor | 3.90 | 0.75 | ||||
| Nkiras2 | NFKB inhibitor interacting Ras-like protein 2 | 2.48 | 0.82 | Irak1bp1 | interleukin-1 receptor-associated kinase 1 binding protein 1 | 0.33 | 1.26 |
| Nfkbiz | Nfkb light polypeptide gene enhancer in B-cells inhibitor, zeta | 3.83 | 0.68 | Irak1 | interleukin-1 receptor-associated kinase 1 | 0.31 | 1.40 |
| Nfat5 | nuclear factor of activated T-cells 5, transcript variant b | 3.34 | 0.71 | ||||
| FC-type receptors | |||||||
| Lilrb4 | Leukocyte immunoglobulin-like receptor, subfamily B, member 4 | 3.60 | 0.74 | ||||
| Mgl1 | macrophage galactose N-acetyl-galactosamine specific lectin 1 | 6.23 | 0.59 | ||||
| Mgl2 | macrophage galactose N-acetyl-galactosamine specific lectin 2 | 2.25 | 0.79 | ||||
| Msr1 | macrophage scavenger receptor 1 | 2.78 | 0.80 | ||||
| Immunoglobulins | |||||||
| Igh-6 | Immunoglobulin heavy chain 6 | 7.43 | 0.56 | ||||
| Igh-6 | Immunoglobulin heavy chain 6 (heavy chain of IgM) | 2.39 | 0.78 | ||||
| Igj | immunoglobulin joining chain | 2.86 | 0.74 | ||||
| Igk-V28 | Immunoglobulin kappa chain variable 28 | 2.82 | 0.79 | ||||
| Igl-V1 | Immunoglobulin lambda chain, variable 1 | 3.69 | 0.76 | ||||
| Igl-V1 | Immunoglobulin lambda chain, variable 1 | 2.03 | 0.82 | ||||
| Igkv4–90 | Immunoglobulin light chain variable region | 1.82 | 0.84 |