Table 3.
Manually selected genes with immunological function based on supervised comparison of evasion and tolerogenic tumor models and tumor rejection model
| Symbol | Description | evasion | tolerogenic | rejection |
|---|---|---|---|---|
| Chemokines | ||||
| Ccl2 | chemokine (C-C motif) ligand 2 | 2.304 | 0.614 | 0.392 |
| Ccl4 | chemokine (C-C motif) ligand 4 | 1.899 | 0.478 | 0.838 |
| Ccl6 | chemokine (C-C motif) ligand 6 | 2.525 | 0.536 | 0.400 |
| Ccr7 | chemokine (C-C motif) receptor 7 | 1.441 | 0.696 | 0.829 |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 2.341 | 0.781 | 0.264 |
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 1.440 | 0.354 | 2.288 |
| Xcl1 | chemokine (C motif) ligand 1 | 4.913 | 0.279 | 0.282 |
| Cx3cl1 | chemokine (C-X3-C motif) ligand 1 | 5.120 | 0.393 | 0.155 |
| Interleukins and signaling | ||||
| Il12b | interleukin 12b | 1.768 | 0.866 | 0.397 |
| Il13 | interleukin 13 | 1.475 | 0.779 | 0.669 |
| Il17d | interleukin 17D | 1.690 | 0.674 | 0.633 |
| Il23r | interleukin 23 receptor | 2.048 | 0.457 | 0.772 |
| Il2rg | interleukin 2 receptor, gamma chain | 1.798 | 0.742 | 0.484 |
| Il4 | interleukin 4 | 2.342 | 0.497 | 0.521 |
| Il4i1 | interleukin 4 induced 1 | 2.290 | 0.701 | 0.325 |
| Il6 | interleukin 6 | 1.105 | 0.504 | 2.291 |
| Il7r | interleukin 7 receptor | 1.218 | 0.439 | 3.063 |
| Il9 | interleukin 9 | 1.711 | 0.801 | 0.477 |
| Tlr11 | toll-like receptor 11 | 2.656 | 0.435 | 0.540 |
| Blnk | B-cell linker | 1.457 | 0.749 | 0.726 |
| Bok | Bcl-2-related ovarian killer protein | 2.071 | 0.432 | 0.822 |
| Vpreb3 | pre-B lymphocyte gene 3 | 2.712 | 0.148 | 2.398 |
| Lcp2 | lymphocyte cytosolic protein 2 | 1.640 | 0.588 | 0.824 |
| Ly6d | lymphocyte antigen 6 complex, locus D | 4.093 | 0.223 | 0.567 |
| Nfkb1 | nfkb light chain gene enhancer 1, p105 | 1.737 | 0.785 | 0.477 |
| Pias2 | Protein inhibitor of activated STAT 2 | 1.336 | 0.502 | 1.458 |
| Pias3 | protein inhibitor of activated STAT 3 | 1.763 | 0.828 | 0.427 |
| Stat4 | signal transducer and activator of transcription 4 | 1.579 | 0.685 | 0.630 |
| Il10 | interleukin 10 | 0.788 | 2.528 | 0.400 |
| Il1r2 | interleukin 1 receptor, type II | 0.804 | 2.504 | 0.391 |
| Il10rb | interleukin 10 receptor, beta | 0.422 | 2.839 | 1.174 |
| Socs1 | suppressor of cytokine signaling 1 | 0.566 | 4.683 | 0.308 |
| Socs3 | suppressor of cytokine signaling 3 | 0.621 | 1.751 | 1.120 |
| Bak1 | BCL2-antagonist/killer 1 | 0.663 | 2.698 | 0.514 |
| Lsp1 | lymphocyte specific 1 | 0.609 | 1.468 | 1.514 |
| Tank | TRAF family member-associated Nf-kappa B activator | 0.718 | 2.204 | 0.351 |
| Tlr6 | toll-like receptor 6 | 0.480 | 1.141 | 3.559 |
| ISGs | ||||
| Ifnb1 | interferon beta 1, fibroblast | 1.388 | 0.644 | 1.003 |
| Irf7 | interferon regulatory factor 7 | 1.500 | 0.677 | 0.406 |
| Ifrd1 | interferon-related developmental regulator 1 | 2.248 | 0.337 | 1.011 |
| Ifnar1 | interferon (alpha and beta) receptor 1 | 1.884 | 0.855 | 0.356 |
| Igtp | interferon gamma induced GTPase | 1.863 | 0.671 | 0.524 |
| Irf1 | interferon regulatory factor 1 | 0.549 | 2.715 | 0.671 |
| Irf3 | interferon regulatory factor 3 | 0.845 | 1.759 | 0.479 |
| Irf6 | interferon regulatory factor 6 | 0.601 | 1.816 | 1.282 |
| Ifngr1 | interferon gamma receptor 1 | 0.582 | 4.515 | 0.308 |
| Ifrg15 | interferon alpha responsive gene | 0.591 | 1.913 | 1.168 |