Table 1.
Patient-Specific Fitted Parameters
| Patient | Proportion of cells in most active state | Fraction of viral replication prevented by drug | β | N |
|---|---|---|---|---|
| Vaccination | 0.016 (0.007, 0.028) | N/A | 5.11 (2.93, 12.76) | 1,089 (668, 1602) |
| era008 | 0.015 (0.004, 0.034) | 0.63 (0.23, 0.98) | 9.95 (3.36, 208.71) | 652 (294, 1677) |
| era014 | 0.030 (0.007, 0.035) | 0.76 (0.24, 0.95) | 8.71 (2.46, 58.07) | 364 (124, 734) |
| era016 | 0.034 (0.008, 0.034) | 0.36 (0.14, 0.78) | 2.84 (1.98, 11.53) | 1,161 (742, 1711) |
| 20452d | 0.034 (0.006, 0.035) | 0.47 (0.16, 0.83) | 3.19 (1.86, 22.05) | 587 (323, 858) |
| 20453e | 0.031 (0.009, 0.034) | 0.54 (0.16, 0.87) | 4.39 (2.38, 28.85) | 538 (278, 859) |
| 20508e | 0.032 (0.006, 0.034) | 0.32 (0.08, 0.80) | 2.82 (2.09, 30.13) | 672 (417, 1019) |
| 3419 | 0.008 (0.004, 0.034) | 0.50 (0.47, 0.52) | 13.95 (5.27, 24.52) | 744 (389, 1025) |
| 3429 | 0.027 (0.009, 0.035) | 0.52 (0.47, 0.54) | 4.36 (2.36, 10.32) | 1,108 (753, 1375) |
| 3431 | 0.007 (0.004, 0.034) | 0.50 (0.43, 0.53) | 15.97 (3.29, 30.69) | 745 (394, 1020) |
Parameter estimates and approximate 95% multivariate confidence bounds, together with transmission variables derived from fitted parameters. Most parameters were fitted to have common values for all patients, with only a few being patient-specific. Parameter estimates quoted refer to the dimensionless equations given in the text; all state variables from these equations need to be multiplied by N to give population size corresponding to 0.02 μl of lymphoid tissue (assuming lymphoid and peripheral blood compartments are of equal volume).