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The responses of 
(A), 
(B), body temperature (C), and 
(D) in unanaesthetized, unrestrained female wild-type (•; n = 6) and 5-HTT knockout mice (○; n = 6) are shown while breathing room air (RA) or 10% O2 in nitrogen during wakefulness. The symbols show the mean values and error bars show s.e.m.*P < 0.001; +P < 0.05, for main treatment and interactive effect.
