FIGURE 5.

Voltage-dependent rates of TOM core complex channels. (A) Voltage dependence of the transition rate between conductance states S5 → S3. Due to the logarithmic scaling of the ordinate, voltage-dependent rates are represented as linearly correlated clusters of data points. Note the bimodal V-shaped relation that indicates that transitions from conductance states S5 to S3 are governed by two almost symmetric processes with rates and In this particular case both rates were voltage-dependent with = 21 ± 9 s⁻¹ and = 0.013 ± 0.005 V⁻¹ and = 9 ± 10 s⁻¹ and = −0.017 ± 0.012 V⁻¹. (B) Topology for the kinetic scheme for TOM core complex gating. The S_X-notation of the kinetic states refers to the conductance class whereas the S ↔ S′ notation indicates the different polarity of the voltage dependence.