Figure 1.

Lack of apoE reduces both Aβ immunoreactive as well as amyloid deposits in a transgenic mouse model of AD. In 21/22-mo-old APP^V717+/− TG mice wild-type for Apoe (APP^V717F+/− Apoe^+/+), numerous thioflavine-S-fluorescent (A) and Aβ immunoreactive deposits (B and C) are evident in both the hippocampus and the cerebral cortex. By contrast, in 21/22-mo-old APP^V717F+/− Apoe^−/− mice, no thioflavine-S-fluorescent Aβ deposits are observed in any brain region. Furthermore, Aβ-immunoreactive deposits are confined to the hippocampus. APP^V717F+/− Apoe^+/− mice had an essentially intermediate level of both thioflavine-S-fluorescent and Aβ immunoreactive deposits. Neither thioflavine-S-fluorescent nor Aβ-immunoreactive deposits were found in APP^V717F−/− Apoe^+/+ mice. The photomicrographs are from representative sections of each of the genotypes indicated. (Original magnification, A and B ×9, C ×35.)