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. 1999 Dec 21;96(26):15239–15244. doi: 10.1073/pnas.96.26.15239

Figure 4.

Figure 4

Offensive intermale aggression in BDNF+/− and WT littermates as assessed in a resident-intruder assay (n = 8–12/group; 2.5–4.5 months of age). (A) Latency to first biting attack. (C) Number of biting attacks measured during five consecutive trials. Repeated measures ANOVA revealed significant differences between the BDNF+/− and WT groups for both biting attack latency (F1,14 = 13.67, P < 0.005) and number of attacks (F1,14 = 9.98, P < 0.01), evident as early as the first trial. (B and D) Chronic Flx treatment in BDNF+/− mice (BDNF+/− flx) normalized both the attack latency (B) and number of attacks (D) to levels found in WT mice administered either vehicle (WT veh) or Flx (WT flx). *, P < 0.05 (ANOVA; different from all other treatment groups whereas no differences were found between the other three groups).