Table 1. LOXL1 allelic frequencies of rs1048661 and rs3825942 in Japanese patients with exfoliation syndrome and controls.
| SNP | p.R141L (rs1048661 G/T) | Odds ratio (95%CI) | p value | p.G153D (rs3825942 G/A) | Odds ratio (95% CI) | p value | |||
|---|---|---|---|---|---|---|---|---|---|
| Allele |
T |
G |
G |
A |
|||||
| Japanese population in this study | |||||||||
| XFS all (n=56) |
0.964 |
0.036 |
26.0 (18.3–37.1) |
7.7x10−18 |
1 |
0 |
- |
4.1x10−4 |
|
| XFG (n=36) |
0.958 |
0.042 |
22.2 (15.9–30.9) |
1.7x10−12 |
1 |
0 |
- |
5.2x10−3 |
|
| XFS no glaucoma (n=20) |
0.975 |
0.025 |
37.9 (25.0–57.5) |
1.5x10−8 |
1 |
0 |
- |
0.027 |
|
| POAG (n=62) |
0.605 |
0.395 |
1.49 (1.25–1.78) |
0.11 |
0.911 |
0.089 |
1.43 (1.07–1.91) |
0.37 |
|
| Control (n=138) |
0.507 |
0.493 |
|
|
0.877 |
0.123 |
|
|
|
| Japanese population in the Western Japanese study* | |||||||||
| XFS all (n=59) |
0.992 |
0.008 |
N/A |
3.0x10−19 |
1 |
0 |
- |
1.4x10−5 |
|
| XFG (n=27) |
1 |
0 |
N/A |
1.1x10−10 |
1 |
0 |
- |
3.0x10−3 |
|
| XFS no glaucoma (n=32) |
0.984 |
0.016 |
N/A |
1.7x10−11 |
1 |
0 |
- |
1.3x10−3 |
|
| Control (n=189) |
0.54 |
0.46 |
|
|
0.857 |
0.143 |
|
|
|
| Icelandic population** | |||||||||
| XFG (n=75) |
0.173 |
0.827 |
2.56 (1.74–3.77) |
1.8x10−6 |
0.987 |
0.013 |
13.23 (5.59–31.29) |
4.1x10−9 |
|
| XFS no glaucoma (n=55) |
0.211 |
0.789 |
2.02 (1.32–3.09) |
1.3x10−3 |
0.982 |
0.018 |
10.10 (4.02–25.36) |
8.5x10−7 |
|
| POAG (n=90) |
0.289 |
0.711 |
1.32 (0.96–1.82) |
0.085 |
0.872 |
0.128 |
1.25 (0.81–1.91) |
0.32 |
|
| Control (n=14,474) | 0.349 | 0.651 | 0.847 | 0.153 | |||||
The single asterisk indicates the data were reported by Hayashi et al. [20], and the double asterisk denotes that the data were reported by Thorleifsson et al. [14]. The significance of the associatio was determined by a contingency table analysis using the χ2 test. CI=confidence interval; N/A=Not applicable in the original report.