TABLE 2.
Quinpirole and nitrendipine reduce forskolin-stimulated cAMP accumulation
| Additions | N | cAMP accumulation(% conversion x 103) |
|---|---|---|
| none | 5 | 53.7 ± 9.7 |
| quinpirole (0.3 μM) | 5 | 49.9 ± 13.9 |
| nitrendipine (3 μM) | 6 | 50.8 ± 8.2 |
| forskolin (1 μM) | 6 | 847.3 ± 45.0 |
| forskolin (1 μM) + quinpirole (0.3 μM) | 6 | 669.5 ± 38.5a |
| forskolin (1 μM) + nitrendipine (3 μM) | 6 | 628.6 ± 51.8a |
| forskolin (1 μM) + quinpirole (0.3 μM) + nitrendipine (3 μM) | 6 | 605.5 ± 35.8a |
Cells were incubated and cAMP accumulation measured as described in Methods.
a
p< 0.05 vs forskolin