Table 4.

Immunohistochemical profiles of malignant spindle cell neoplasms of the lung

	PKa	VIM	Actin	CD31	CD34	CD68	CD99	S100	HMB45	EMA	CALR
Spindle cell carcinoma	+b	++	−−	−−	−−	−−	−−	−−	−−	+	−−
Melanoma	−−	+	−−	−−	−−	−−	−−	++	+	−−	−−
Leiomyosarcoma	−−	++	++	−−	−−	−−	−−	−−	−−	−−	−−
Kaposi's sarcoma	−−	++	+	+	++	−−	−−	−−	−−	−−	−−
MFH	−−	++	+	−−	+	++	−−	−−	−−	−−	−−
Synovial sarcoma	+	+	+	−−	−−	−−	+	−−	−−	+	−−

^aPK: pan-cytokeratin; VIM: vimentin; EMA: epithelial membrane antigen; CALR: calretinin.

^b++, almost always positive; +, mostly positive with variable staining; −−, almost always negative.