The massive TILs are positive for CD3 (A, ×400), CD8 (B, ×400) and the cytotoxic molecule granzyme B (C, ×400). The SCCAC cells show overexpression of P63 (D, ×250) and P53 (E, ×250). The tumor cells are also positive for HPV (F, HPV fam 16, high risk, ×250).