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Pre-administration of HGF gene prevents acute renal failure after ischemia/reperfusion injury. Mice were administrated HGF expression plasmid (pCMV-HGF) or control vector (pcDNA3). Serum creatinine levels were determined at day 2 after ischemia/reperfusion (I/R). **P < 0.01 verse sham controls. †P < 0.01 verse I/R controls (n = 4). Pre-admini., HGF gene was given 24 hours prior to I/R. Simul. Admini., HGF gene was given at the same time with I/R.
