TABLE 3.

Residues identified as among the top five residues closest to the bottleneck region, for the full model channel near open and closed states

Closed		Open
Axial position range (Å)	Residues	Axial position range (Å)	Residues
21–26	S411, N414, Y415, H418, R419	33–35	V406, P407, I409, V410
29–32	P407, V410, S411, F413, N414	37–38.5	V406
35–36	V406

Position ranges are based on the left-hand panels in Fig. 10. Underscoring indicates that the residue was at least once the closest residue (see Methods).