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. 2008 Jul 1;99(2):305–313. doi: 10.1038/sj.bjc.6604473

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Copyright © 2008 Cancer Research UK

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Expression patterns of FGFR2 and FGF10 in normal pancreas and pancreatic cancer. The magnification is shown in the right bottom corner of each figure. (A and B) Immunostaining of FGFR2 (A) and FGF10 (B) in normal pancreas, showing that FGFR2 is expressed weakly in ductal cells (A, arrow) and acinar cells (A, arrow head), and that no obvious FGF10 staining is found in normal pancreatic tissue, including ductal cells (B, arrows). (C and D) Immunostaining of FGFR2 (C) and FGF10 (D) in pancreatic cancer tissues, showing that FGFR2 is expressed in cancer cells (C), whereas FGF10 is expressed in scattered cells in the stroma surrounding cancer cells (D, arrows). (E and F) Immunostaining of FGFR2 in pancreatic cancer cells. (E) Representative result from the FGFR2 high expression group, indicating higher FGFR2 expression in cancer cells (arrows) compared with islets (arrow head). (F) Representative result from the FGFR2 low expression group, showing lower FGFR2 expression in cancer cells (arrows) compared with islet (arrow heads). (G and H) Immunostaining of FGF10 (G) and CD3 (H), marker for T cell. Fibroblast growth factor 10 and CD3 are both expressed in scattered cells with similar cell shape in the stroma surrounding cancer cells (arrows).