Table 1. Frequency of LKB1 mutations in NSCLC tumours and their association with clinicopathological characteristics.

	LKB1 mutation
	+	−	P-value*
All tumours	34 (11%)	276 (89%)
Age, median	61.2	62.2
Ethnicity
Caucasian cohort	25 (17%)	118 (83%)	0.001
Asian cohort	9 (5%)	158 (95%)
Gender
Male	20 (11%)	167 (89%)	NS
Female	14 (12%)	107 (88%)
Smoking
Never (<10 py)	2 (3%)	70 (97%)	0.007
Smoker (>10 py)	26 (14%)	161 (86%)
Tumour stage
I	19 (10%)	169 (90%)	NS
II	8 (14%)	51 (86%)
III	5 (11%)	42 (89%)
IV	1 (12%)	7 (88%)
Histology
Adenocarcinoma	27 (13%)	180 (87%)	0.047
Squamous carcinoma	5 (5%)	87 (95%)
Adenosquamous	2 (22%)	7 (78%)

^*Fisher's exact test, NS=not statistically significant (P>0.05).