Table 2. The specific LKB1 mutations in NSCLC tumours.
| Mutation type | No. (%) | Mutation | Amino acid change | Exon | Histology |
|---|---|---|---|---|---|
| Missense | 7 (21) | a526G>T | D176Y | 4 | Ad |
| a580G>T | D194Y | 4 | Ad | ||
| 580G>T | D194Y | 4 | Sq | ||
| 829G>T | D277Y | 6 | AdSq | ||
| a842C>T | P281L | 6 | Ad | ||
| a842C>T | P281L | 6 | Ad | ||
| 1276C>T | R426W | 9 | Ad | ||
| Nonsense | 2 (6) | 206C>A | S69X | 1 | Ad |
| 475C>T | Q159X | 4 | Ad | ||
| Deletion/ insertion | 25 (74) | a75_76del2&insT | FS, truncates | 1 | Ad |
| 120_130del11 | FS, truncates | 1 | Ad | ||
| 125_127insGG | FS, truncates | 1 | Ad | ||
| 128_129delC | FS, truncates | 1 | Ad | ||
| 142_143delA | FS, truncates | 1 | Ad | ||
| 180delC | FS, truncates | 1 | Ad | ||
| 209delA | FS, truncates | 1 | Ad | ||
| 227_228delC | FS, truncates | 1 | Ad | ||
| 47_651del604 | FS, truncates | 1-5 | Sq | ||
| 153_536del384 | FS, truncates | 1-4 | AdSq | ||
| aexon 2-3del | Truncates | 2-3 | Sq | ||
| aexon 2-3del | Truncates | 2-3 | Ad | ||
| exon 2-3del | Truncates | 2-3 | Ad | ||
| exon 2-4del | FS, truncates | 2-4 | Sq | ||
| 464_465del2insTTTGCT | FS, truncates | 3-4 | Sq | ||
| 562_563delG | FS, truncates | 4 | Ad | ||
| aexon 4del | FS, truncates | 4 | Ad | ||
| exon 4del | FS, truncates | 4 | Ad | ||
| exon 4del | FS, truncates | 4 | Ad | ||
| exon 4del | FS, truncates | 4 | Ad | ||
| 610_623del14 | FS, truncates | 5 | Ad | ||
| a837_844delC | FS, truncates | 6 | Ad | ||
| 837_844insC | FS, truncates | 6 | Ad | ||
| exon 6del | FS, truncates | 6 | Ad | ||
| 1038_1040insG | FS, truncates | 8 | Ad |
Ad=Adenocarcinoma; AdSq=Adenosquamous carcinoma; Sq=Squamous cell carcinoma; .
a
These mutations were detected in Korean NSCLC patients.