Table 3. Relationship between proteins and clinicopathological characteristics.
HER2
|
EGFR
|
pEGFR
|
pAKT
|
pERK
|
PTEN
|
|||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variable | Neg | Pos | P | Neg | Pos | P | Neg | Pos | P | Neg | Pos | P | Neg | Pos | P | Neg | Pos | P |
Age | ||||||||||||||||||
<58 years | 110/113 | 3/113 | 0.14 | 106/112 | 6/112 | 0.44 | 99/113 | 14/113 | 0.84 | 104/114 | 10/114 | 1.00 | 69/108 | 39/108 | 0.89 | 38/111 | 73/111 | 0.31 |
>58 years | 108/117 | 9/117 | 106/116 | 10/116 | 102/115 | 13/115 | 105/114 | 9/114 | 71/114 | 43/114 | 31/113 | 82/113 | ||||||
Stage | ||||||||||||||||||
Early | 59/62 | 3/62 | 1.00* | 56/61 | 5/61 | 0.77* | 51/60 | 9/60 | 0.49 | 60/91 | 1/61 | 0.029 | 38/59 | 21/59 | 0.88 | 27/60 | 33/60 | 0.006 |
Late | 157/166 | 9/166 | 154/165 | 11/165 | 148/166 | 18/166 | 147/165 | 18/165 | 101/161 | 60/161 | 41/162 | 121/162 | ||||||
Histology | ||||||||||||||||||
Serous | 123/128 | 5/128 | 0.38 | 123/127 | 4/127 | 0.017 | 111/127 | 16/127 | 0.84 | 115//126 | 11/126 | 1.00 | 77/123 | 46/123 | 0.89 | 31/124 | 93/124 | 0.042 |
Other | 95/102 | 7/102 | 89/101 | 12/101 | 90/101 | 11/101 | 94/102 | 8/102 | 63/99 | 36/99 | 38/100 | 62/100 | ||||||
Grade | ||||||||||||||||||
I/II | 84/89 | 5/89 | 1.00* | 82/87 | 5/87 | 0.78 | 75/88 | 13/88 | 0.18 | 85/89 | 4/89 | 0.19 | 49/85 | 36/85 | 0.24 | 32/87 | 55/87 | 0.17 |
III/undiff | 112/118 | 6/118 | 109/118 | 9/118 | 107/117 | 10/117 | 104/116 | 12/116 | 76/114 | 38/114 | 31/114 | 83/114 | ||||||
Res. tumour | ||||||||||||||||||
<2 cm | 105/109 | 4/109 | 0.54 | 100/107 | 7/107 | 1.00 | 95/107 | 12/107 | 0.84 | 102/108 | 6/108 | 0.31 | 70/102 | 32/102 | 0.15 | 34/104 | 70/104 | 0.55 |
⩾ 2 cm | 102/109 | 7/109 | 101/109 | 8/109 | 95/109 | 14/109 | 97/108 | 11/108 | 63/108 | 45/108 | 31/108 | 77/108 |
Neg=negative; Pos=positive; Res. tumour=residual tumour after primary surgery; undiff=undifferentiated.
P-values are derived from the χ2-test or Fischer's exact test, where appropriate (*signifies the use of the Fischer's exact test).