Table 2. Univariate and multivariate Cox proportional hazards models in estimating time to disease-specific death.

Covariates	Regression coefficient	s.e.	Risk ratio	Probability
Age, years	−0.014	0.025	0.986	0.567
Sex (male vs female)	0.813	0.758	2.254	0.284
Stage (I–II vs III–IV)	0.012	0.667	1.012	0.985
Adjuvant therapya (yes vs no)	0.306	0.548	1.358	0.577
Histopathological gravity sign (yes vs no)	0.377	0.602	1.458	0.531
Hypermethylation informative (− vs +)	1.341	0.602	3.823	0.026b

^aConcurrent chemoradiotherapy or radiotherapy alone.

^bNo covariate other than tumour methylation status was entered in the multivariate analyses, because P>0.10 for all other covariates.