Effects of ADX and steroid replacement therapy on COX-2 expression in rat kidney cortex. Immunoblots of microsomes: lane 1, faint signal in sham-operated control rat; lane 2, increased signal after ADX for 1 week; lane 3, maximum signal after 2 weeks ADX; lane 4, 2 weeks ADX with concurrent CS replacement; lane 5, 2 weeks ADX with CS replacement after 1 week; and lane 6, 2 weeks ADX with concurrent DOCA replacement.