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. 2008 Jul 30;3(7):e2789. doi: 10.1371/journal.pone.0002789

Figure 1. Empirical and model-predicted inflammatory and wound healing responses to acute phonotrauma in a single human subject (Subject 3) following spontaneous speech (Panels A–C), voice rest (Panels D–F) and resonant voice treatment conditions (Panels G–I).

Figure 1

Panels A, D and G display empirical and predicted trajectories of IL-1β. Panels B, E and H show empirical and predicted trajectories of TNF-α. Panels C, F and I show empirical and predicted trajectories of IL-10. Inflammatory marker concentrations are in pg/ml. The grey bars represent the mean of the simulated data, and the error bars represent standard deviations in the simulated data. The dark circles represent the input data for the first three time-points (baseline, post-loading, 4-hr post treatment onset), obtained from human laryngeal secretion data. The empty circles represent the validation data at the 24-hr time point from the human laryngeal secretion data. B: baseline; PL: post vocal loading; 4hrPRx: following a 4-hr treatment. Note that human validation data for Days 2–5 have not yet been generated.