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. 2008 Jul 2;3(7):e2548. doi: 10.1371/journal.pone.0002548

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Gu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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This figure shows results from microRNA microarray combined with mRNA data obtained through Affymetrix expression array profiling. Panel A shows miRNA-mRNA relationships based on TargetScan and Panel B shows miRNA-mRNA relationships based on miRanda. Here we see that in general Class 1 miRNAs are positively correlated in their expression trends as compared with their predicted targets. By contrast, Class 3 miRNAs are negatively correlated. Significant miRNA-mRNA relationships are determined through an enrichment analysis, which, is described in the methods section and results are shown in Table 1.