Table 1.
Patient characteristics at intensive care unit admission
| Intention to treat | Modified intention to treat | |||||
| Antibiotic treatment n = 22 |
No antibiotic treatment n = 36 |
P value | Antibiotic treatment n = 18 |
No antibiotic treatment n = 26 |
P value | |
| Age, years | 62 ± 15 | 67 ± 12 | 0.194 | 61 ± 15 | 67 ± 12 | 0.321 |
| Male gender | 15 (68) | 24 (66) | >0.999 | 13 (72) | 16 (61) | 0.531 |
| SAPS II | 47 ± 14 | 47 ± 18 | 0.994 | 45 ± 17 | 48 ± 15 | 0.481 |
| LOD score | 6.6 ± 3.5 | 6.2 ± 3.6 | 0.711 | 6.5 ± 3.8 | 6.4 ± 3.9 | 0.990 |
| McCabe | 0.687 | 0.625 | ||||
| Nonfatal underlying disease | 10 (45) | 14 (38) | 10 (55) | 11 (42) | ||
| Ultimately fatal underlying disease | 9 (40) | 17 (47) | 7 (38) | 12 (46) | ||
| Rapidly fatal underlying disease | 3 (13) | 5 (13) | 1 (5) | 3 (11) | ||
| Admission category | >0.999 | 0.409 | ||||
| Medical | 19 (86) | 30 (83) | 15 (83) | 21 (80) | ||
| Surgical | 3 (13) | 5 (13) | 3 (16) | 4 (15) | ||
| Trauma | 0 (0) | 1 (2) | 0 (0) | 1 (3) | ||
| Comorbidities | ||||||
| COPD | 9 (40) | 17 (47) | 0.787 | 7 (38) | 12 (46) | 0.760 |
| Cardiac failure | 6 (27) | 4 (11) | 0.156 | 6 (33) | 3 (11) | 0.128 |
| Cirrhosis | 0 (0) | 3 (8) | 0.281 | 0 (0) | 3 (11) | 0.258 |
| Chronic dialysis | 4 (18) | 2 (5) | 0.187 | 3 (16) | 1 (3) | 0.289 |
| Diabetes mellitus | 6 (27) | 3 (8) | 0.070 | 5 (27) | 3 (11) | 0.204 |
| Transfer from other wards | 12 (54) | 12 (33) | 0.285 | 9 (50) | 9 (34) | 0.361 |
| Prior antibiotic treatment | 9 (40) | 12 (33) | 0.585 | 8 (44) | 8 (30) | 0.525 |
| Infection at ICU admission | 18 (81) | 25 (69) | 0.365 | 14 (77) | 20 (76) | >0.999 |
| Cause for ICU admission | ||||||
| Community-acquired pneumonia | 6 (27) | 10 (27) | >0.999 | 6 (33) | 6 (23) | 0.506 |
| Acute exacerbation of COPD | 3 (13) | 14 (38) | 0.073 | 3 (16) | 9 (34) | 0.303 |
| Congestive heart failure | 3 (13) | 1 (2) | 0.319 | 3 (16) | 1 (3) | 0.289 |
| Neurologic failure | 2 (9) | 5 (13) | 0.698 | 1 (5) | 4 (15) | 0.634 |
| Acute poisoning | 2 (9) | 2 (5) | 0.681 | 2 (11) | 2 (7) | >0.999 |
| Others | 6 (27) | 4 (11) | 0.156 | 3 (16) | 4 (15) | >0.999 |
Results of univariate analysis are presented. Data are expressed as frequency (percentage) or mean ± standard deviation. COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; LOD, logistic organ dysfunction; SAPS, Simplified Acute Physiology Score.