Table 2.
Intention to treat | Modified intention to treat | |||||
Antibiotic treatment n = 22 |
No antibiotic treatment n = 36 |
P value | Antibiotic treatment n = 18 |
No antibiotic treatment n = 26 |
P value | |
Duration of mechanical ventilation before random assignment, days | 17 ± 9 | 13 ± 6 | 0.232 | 17 ± 10 | 12 ± 6 | 0.113 |
SAPS II | 33 ± 13 | 36 ± 13 | 0.195 | 32 ± 10 | 36 ± 12 | 0.120 |
LOD score | 4.1 ± 2 | 4.9 ± 2.4 | 0.185 | 3.8 ± 1.5 | 4.8 ± 2.6 | 0.210 |
Temperature, °C | 38.1 ± 0.6 | 38.3 ± 0.6 | 0.408 | 38.2 ± 0.5 | 38.2 ± 0.4 | 0.402 |
Leucocytes, × 109 cells/L | 12 ± 5.9 | 12 ± 6 | 0.619 | 11.2 ± 4.2 | 11.9 ± 5.7 | 0.775 |
C-reactive protein, mg/mL | 111 ± 61 | 104 ± 80 | 0.417 | 104 ± 50 | 95 ± 67 | 0.295 |
Procalcitonin, ng/mL, median (IR) | 0.6 (0.10–3.1) | 0.8 (0.5–2.7) | 0.282 | 0.7 (0.05–2.8) | 0.83 (0.36–2.1) | 0.494 |
Results of univariate analysis are presented. Data are expressed as mean ± standard deviation unless otherwise indicated. IR, interquartile range; LOD, logistic organ dysfunction; SAPS, Simplified Acute Physiology Score.