Table 6.
Classification of serum HMGB1, number of SIRS criteria, SAPS II score and PaO2/FiO2 ratio according to the HMGB1 982C>T and -1377delA genotypes
| Variable | 982C>T genotype | -1377delA genotype | ||
| C/C | C/T | A/A | A/- or -/- | |
| Serum HMGB1 (ng/μl) | 1.45 ± 3.05 | 0.28 ± 0.96* | 1.36 ± 2.78 | 1.61 ± 4.43 |
| Number of SIRS criteria | 3.13 ± 0.81 | 3.83 ± 0.39* | 3.21 ± 0.80 | 2.76 ± 0.78* |
| SAPS II | 37.8 ± 15.2 | 43.9 ± 12.3 | 38.2 ± 15.3 | 36.8 ± 13.8 |
| PaO2/FiO2 ratio | 164 ± 94 | 89 ± 38* | 158 ± 96 | 182 ± 63 |
Data presented as mean ± standard deviation. *P = 0.01. HMGB1, high mobility group box 1 protein; PaO2/FiO2 = ratio between partial pressure of oxygen and fraction of inspired oxygen; SAPS II, Simplified Acute Physiology score II; SIRS, systemic inflammatory response syndrome.