. 2008 May 9;10(3):R42. doi: 10.1186/bcr2093

Table 3.

Means and correlations of IGFBP-3 levels with mammographic breast density

	Adjusted means of percent density (percentage)^a			Adjusted means of absolute density (cm²)^a,b
Levels of IGFBP-3	Intact^c	Fragmented^d	Total^e	Intact^c	Fragmented^d	Total^e
Quartile 1 (n = 185)	42.2	45.3	44.5	48.6	48.3	49.4
Quartile 2 (n = 184)	42.9	44.3	44.7	46.3	48.0	48.6
Quartile 3 (n = 184)	40.4	40.3	40.7	45.7	45.9	45.0
Quartile 4 (n = 184)	44.0	39.6	39.6	45.5	43.9	43.1
r^f(P)	0.075 (0.04)	-0.171 (< 0.0001)	-0.151 (< 0.0001)	-0.010 (0.79)	-0.092 (0.01)	-0.094 (0.01)
r^f(P)^a	0.031 (0.40)	-0.105 (0.004)	-0.095 (0.01)	-0.029 (0.43)	-0.066 (0.07)	-0.075 (0.04)
r^f(P)^g	0.022 (0.55)	-0.112 (0.003)	-0.104 (0.005)	-0.042 (0.26)	-0.078 (0.04)	-0.090 (0.02)

^aMeans and correlations are adjusted for age, body mass index, waist-to-hip ratio, alcohol intake, energy intake, physical activity, parity, smoking status, and total IGF-I levels. ^bMeans of absolute density are presented as back-transformed values; square-root-transformed absolute density is used in the correlation. ^cQuartiles of intact IGFBP-3 are ≤883.80, 883.81 to 1,021.00, 1,021.01 to 1,170.50, and > 1,170.50 ng/mL. ^dQuartiles of fragmented IGFBP-3 are ≤3,137.50, 3,137.51 to 3,662.50, 3,662.51 to 4,263.00, and > 4,263.00 ng/mL. ^eQuartiles of total IGFBP-3 are ≤4,183.0, 4,183.1 to 4,695.0, 4,695.1 to 5,290.0, and > 5,290.0 ng/mL. ^fPearson correlation between continuous variables; adjusted correlations are partial Pearson coefficients. ^gCorrelations are adjusted for age, body mass index, waist-to-hip ratio, alcohol intake, energy intake, physical activity, parity, smoking status, total IGF-I levels, age at menarche, number of full-term pregnancies, age at first full-term pregnancy, lactation, family history of breast cancer, number of breast biopsies, education, past use of oral contraceptives, past use of hormone replacement therapy, and height.