Table 2.
Effect of kainic acid administration on seizure parameters in young, middle-aged, and aged mice
| Mouse strain | Age group | Dose (mg/kg) | Seizure incidence | Latency (min.) | Duration (min.) | Mortality |
|---|---|---|---|---|---|---|
| FVB/NJ | Young | 15 | 9/9 | 48.8±5.2 | 39.7±10.2 | 4/9 |
| FVB/NJ | Young | 20 | 9/10 | 62.7±8.3 | 58.2±9.7 | 4/10 |
| FVB/NJ | Young | 25 | 10/10 | 69.4±2.2 | 70.6±8.5 | 5/10 |
| FVB/NJ | Young | 30 | 20/20 | 46.2±4.7 | 56.3±7.0 | 12/20 |
|
| ||||||
| FVB/NJ | Mature | 10 | 5/6 | 34.3±7.3 | 64.2±18.6 | 3/6 |
| FVB/NJ | Mature | 15 | 13/13 | 34.3±3.3 | 52.5±11.7 | 9/13 |
| FVB/NJ | Mature | 20 | 13/13 | 37.3±4.5 | 68.9±6.3 | 9/13 |
|
| ||||||
| FVB/NJ | Aged | 10 | 7/7 | 65.7±7.6 | 62.9±14.9 | 5/7 |
| FVB/NJ | Aged | 15 | 6/6 | 28.3±3.6 | 60.3±8.6 | 3/6 |
| FVB/NJ | Aged | 20 | 5/5 | 24.8±4.1 | 50.6±20.1 | 2/6 |