Table 3.

Age-response comparison of hippocampal cell loss (percentage) following kainate administration in FVB/NJ mice

Hippocampal subregion	Dose (mg/kg)	Young Adult	Mature	Aged	P-value
Hilus	10	N/A	3.3±2.2	50.1±13.5*	0.001
	15	34.8±2.5	64.8±14.8	94.4±5.6*	0.003
	20	36.6±7.0	76.0±13.9	48.1±13.4
CA3	10	N/A	0.9±1.0	4.5±0.1*	0.041
	15	55.0±2.3	55.8±12.1	79.4±6.1
	20	57.0±7.3	78.7±12.1	62.2±11.2
CA1	10	N/A	0.1±0.9	1.8±0.5
	15	47.5±1.0	46.6±16.9	72.0±6.8
	20	46.5±11.5	64.6±16.8	15.6±8.8*	<0.001

Values represent means ± S.E.M. of at least 5 mice in each age group.

^*P<0.05 as compared to other age groups.