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. Author manuscript; available in PMC: 2008 Jul 23.
Published in final edited form as: Neuroscience. 2008 Mar 19;153(3):605–617. doi: 10.1016/j.neuroscience.2008.02.076

Fig. 1.

Fig. 1

Exaggeration of PVN responses by blockade of glutamate receptors in the mNTS. The rats were barodenervated. Black and open bars: responses to unilateral microinjections of NMDA (10 mM, 50 nl) into the PVN before and after, respectively, the bilateral microinjections of NBQX (2 mM, 50 nl) and D-AP7 (5 mM, 50 nl) into the mNTS (n = 8). A: The increases in MAP elicited by the PVN stimulation before and after the blockade of ionotropic glutamate receptors in the mNTS were 31.3 ± 2.6 and 40.6 ± 4.8 mmHg, respectively. B: The increases in the greater splanchnic nerve activity (GSNA) before and after the same treatment were 47.1 ± 6.9 and 80.3 ± 10.7 %, respectively. C: The increases in HR before and after the same treatment were 28.8 ± 6.1 and 30.0 ± 4.6 bpm, respectively. Baseline MAP before and after the bilateral microinjections of ionotropic glutamate receptor antagonists into the mNTS were 85.6 ± 4.0 and 91.9 ± 4.6 mmHg, respectively (P > 0.05). Baseline HR was 428.8 ± 12.7 and 425.0 ± 13.5 bpm, respectively (P > 0.05). *P < 0.05, **P < 0.01 compared with the values before the microinjections of ionotropic glutamate receptor antagonists into the mNTS.