Table 2.
The Pathway Express Results Ranking the KEGG Pathways Incorporating the 1844 Differentially Expressed Genes in PA.
| Rank | Unique Pathway ID | KEGG Database Pathway Name | Impact Factor | Genes in Pathway | Pathway Genes in Input (%) |
|---|---|---|---|---|---|
| 1 | 1:04612 | Antigen processing and presentation | 76.6 | 86 | 24.4 |
| 2 | 1:04514 | Cell adhesion molecules (CAMs) | 24.1 | 132 | 25.8 |
| 3 | 1:04070 | Phosphatidylinositol signaling system | 23.2 | 79 | 27.8 |
| 4 | 1:04510 | Focal adhesion | 14.7 | 194 | 25.8 |
| 5 | 1:04010 | MAPK signaling pathway | 14.3 | 273 | 22.7 |
| 6 | 1:04810 | Regulation of actin cytoskeleton | 12.9 | 206 | 23.3 |
| 9 | 1:04210 | Apoptosis | 9.3 | 84 | 27.4 |
| 10 | 1:04540 | Gap junction | 9.3 | 99 | 25.3 |
| 11 | 1:04512 | ECM-receptor interaction | 9.1 | 87 | 26.4 |
| 12 | 1:04610 | Complement and coagulation cascades | 8.8 | 69 | 27.5 |
| 14 | 1:04620 | Toll-like receptor signaling pathway | 8.1 | 91 | 25.3 |
| 16 | 1:04670 | Leukocyte transendothelial migration | 7.8 | 117 | 23.1 |
| 17 | 1:04650 | Natural killer cell mediated cytotoxicity | 7.3 | 128 | 21.1 |
| 18 | 1:04662 | B-cell receptor signaling pathway | 7.2 | 63 | 27.0 |
| 19 | 1:04020 | Calcium signaling pathway | 7.0 | 176 | 18.2 |
| 24 | 1:04910 | Insulin signaling pathway | 5.7 | 135 | 20.7 |
| 25 | 1:01510 | Neurodegenerative disorders | 5.7 | 35 | 28.6 |
| 26 | 1:05210 | Colorectal cancer | 5.6 | 77 | 23.4 |
| 28 | 1:04310 | Wnt signaling pathway | 5.5 | 147 | 18.4 |
| 32 | 1:04080 | Neuroactive ligand-receptor interaction | 4.7 | 302 | 11.3 |
| 33 | 1:04660 | T cell receptor signaling pathway | 4.4 | 93 | 20.4 |
| 35 | 1:04920 | Adipocytokine signaling pathway | 4.0 | 69 | 20.3 |
| 36 | 1:04530 | Tight junction | 3.9 | 119 | 16.8 |
| 37 | 1:04520 | Adherens junction | 3.8 | 77 | 20.8 |
| 38 | 1:04110 | Cell cycle | 3.5 | 112 | 16.1 |
| 39 | 1:04370 | Vascular endothelial growth factor (VEGF) signaling pathway | 3.0 | 72 | 16.7 |
| 42 | 1:04150 | mTOR signaling pathway | 2.6 | 49 | 18.4 |
| 43 | 1:04130 | SNARE interactions in vesicular transport | 2.5 | 36 | 13.9 |
| 44 | 1:04350 | TGFβ signaling pathway | 2.3 | 84 | 15.5 |
| 45 | 1:04630 | Jak-STAT signaling pathway | 2.2 | 153 | 13.7 |
| 46 | 1:04340 | Hedgehog signaling pathway | 1.6 | 57 | 12.3 |
| 47 | 1:04060 | Cytokine-cytokine receptor interaction | 1.6 | 256 | 11.7 |
| 51 | 1:04140 | Regulation of autophagy | 0.8 | 29 | 3.4 |
| 52 | 1:04330 | Notch signaling pathway | 0.8 | 46 | 8.7 |
The pathways are ranked according to impact factor, taking into account the fold change, the number of genes disrupted in a pathway, and the influence each gene exerts on a pathway.