Figure 3.

Identification of Ets as the Akt-response element. (A) Schematic representation of the Aurora A promoter luciferase constructs. (B and C) H1299 cells were transfected with the indicated Aurora A promoter constructs at indicated concentrations. Experiments were done as in Figure 2. Data are representative of three independent experiments. (D and E) H1299 cells were transfected with either pGL-147bp (D) or pGL-142bp (E). Approximately 8 hours later, Compound A or B was added, and the luciferase activities were assessed 24 hours later.