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. 2008 Jul 14;8:10. doi: 10.1186/1471-2466-8-10

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Copyright © 2008 Hilgendorff et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ventilation efficiency index (VEI). Left panel. Time course of ventilation efficiency index (VEI) over the observation period. Induction of lung injury by repetitive lavage procedures (T = 0) is followed by open lung concept positive pressure ventilation (PPV_OLC; n = 5) or surfactant treatment under conventional positive pressure ventilation with a natural bovine surfactant (Alveofact^®; nat SF; n = 4) or a modified monomeric surfactant protein B surfactant (mon SP-B; n = 4). Right panel. Difference of VEI over the study period (T5-T0). Study groups: open lung concept positive pressure ventilation (PPV_OLC; n = 5); surfactant treatment under conventional positive pressure ventilation with a modified monomeric surfactant protein B surfactant (mon SP-B; n = 4) or a natural bovine surfactant (Alveofact^®; nat SF; n = 4). Results are given as mean and standard deviation. * p < 0.05 vs PPV_OLC.