Table 2.
Gas exchange and lung function variables
| a. Gas exchange and lung function variables at different time points | |||||||
| Pao2 | PaCO2 | Cdyn/kg | VT/kg | Res | VEI | ΔP | |
| Healthy (H) | |||||||
| PPVOLC | 74.21 ± 16.75 | 5.67 ± 2.05 | 1.94 ± 0.89 | 16.0 ± 4.8 | 37.62 ± 8.09 | 0.29 ± 0.17 | 10.20 ± 0.45 |
| mon SP-B | 64.11 ± 34.10 | 3.75 ± 0.75 | 2.56 ± 0.50 | 20.4 ± 2.7 | 40.50 ± 8.63 | 0.35 ± 0.08 | 10.00 ± 0.00 |
| nat SF | 78.44 ± 15.09 | 5.29 ± 1.95 | 2.12 ± 0.87 | 19.2 ± 7.0 | 37.88 ± 7.43 | 0.29 ± 0.14 | 10.25 ± 0.50 |
| Lavaged (T = 0) | |||||||
| PPVOLC | 6.70 ± 3.04 ** | 6.95 ± 2.84 | 0.56 ± 0.23 * | 11.3 ± 2.6 | 52.43 ± 13.53 * | 0.10 ± 0.06 * | 20.00 ± 0.00 |
| mon SP-B | 9.24 ± 0.79* | 3.86 ± 1.64 | 1.21 ± 0.42 * | 21.0 ± 5.0 | 63.28 ± 15.30 * | 0.11 ± 0.02 ** | 20.00 ± 0.00 |
| nat SF | 8.16 ± 1.26 ** | 5.57 ± 1.35 | 0.88 ± 0.35 * | 16.3 ± 5.4 | 50.25 ± 11.95 * | 0.10 ± 0.04 * | 20.00 ± 0.00 |
| 1 h | |||||||
| PPVOLC | 9.68 ± 2.26 | 6.91 ± 2.07 | 0.57 ± 0.20 | 11.3 ± 4.5 | 47.50 ± 12.90 | 0.09 ± 0.04 | 20.00 ± 0.00 |
| mon SP-B | 38.60 ± 24.14 | 3.83 ± 2.84 | 1.52 ± 0.66 | 22.9 ± 8.4 | 58.55 ± 14.04 | 0.16 ± 0.09 | 19.50 ± 1.00 |
| nat SF | 56.86 ± 14.62 | 3.75 ± 1.13 | 1.50 ± 0.43 | 23.1 ± 6.2 | 53.98 ± 14.52 | 0.14 ± 0.05 | 20.00 ± 0.00 |
| 2 h | |||||||
| PPVOLC | 71.45 ± 20.29 | 4.49 ± 1.97 | 1.03 ± 0.38 | 10.2 ± 2.2 | 34.34 ± 8.13 | 0.33 ± 0.20 | 12.60 ± 1.82 |
| mon SP-B | 64.87 ± 29.48 | 3.51 ± 0.91 | 1.53 ± 0.10 | 16.1 ± 7.0 | 47.80 ± 20.69 | 0.33 ± 0.27 | 13.75 ± 3.86 |
| nat SF | 75.18 ± 19.67 | 4.12 ± 0.41 | 1.39 ± 0.31 | 18.6 ± 4.0 | 45.20 ± 7.52 | 0.16 ± 0.02 | 17.75 ± 1.71 |
| 3 h | |||||||
| PPVOLC | 74.08 ± 12.99 | 5.19 ± 2.35 | 1.13 ± 0.75 | 9.9 ± 3.0 | 34.76 ± 10.65 | 0.30 ± 0.19 | 12.40 ± 2.07 |
| mon SP-B | 59.05 ± 33.81 | 4.77 ± 1.11 | 1.23 ± 0.14 | 14.7 ± 4.1 | 50.63 ± 14.95 | 0.19 ± 0.12 | 14.00 ± 3.74 |
| nat SF | 72.32 ± 17.01 | 4.81 ± 0.55 | 1.15 ± 0.30 | 17.1 ± 5.0 | 43.85 ± 9.29 | 0.15 ± 0.04 | 17.00 ± 0.82 |
| 4 h | |||||||
| PPVOLC | 70.09 ± 12.32 | 5.54 ± 1.67 | 1.11 ± 0.73 | 9.7 ± 2.4 | 35.46 ± 7.11 | 0.26 ± 0.15 | 12.60 ± 3.21 |
| mon SP-B | 60.05 ± 33.26 | 4.73 ± 1.28 | 1.21 ± 0.15 | 14.8 ± 3.4 | 53.70 ± 19.89 | 0.18 ± 0.11 | 14.50 ± 3.87 |
| nat SF | 56.53 ± 11.97 | 5.37 ± 0.53 | 1.05 ± 0.27 | 15.5 ± 2.8 | 44.18 ± 11.66 | 0.14 ± 0.04 | 16.50 ± 0.58 |
| 5 h | |||||||
| PPVOLC | 71.61 ± 9.23 | 5.25 ± 1.01 | 0.97 ± 0.51 | 9.6 ± 3.2 | 35.78 ± 8.46 | 0.25 ± 0.14 | 12.80 ± 3.27 |
| mon SP-B | 60.38 ± 33.21 | 5.49 ± 1.17 | 1.04 ± 0.22 | 13.1 ± 3.7 | 51.93 ± 14.55 | 0.16 ± 0.08 | 14.0 ± 4.69 |
| nat SF | 48.94 ± 20.65 | 5.20 ± 0.52 | 1.01 ± 0.25 | 15.0 ± 2.2 | 50.55 ± 13.11 | 0.12 ± 0.04 | 17.00 ± 0.82 |
| b. Overall differences in gas exchange and lung function variables (T5 - T0) | |||||||
| Pao2 | PaCO2 | Cdyn/kg | VT/kg | Res | VEI | ΔP | |
| T5 - T0 | |||||||
| PPVOLC | 64.90 ± 9.22 | -1.71 ± 2.57 | 0.42 ± 0.40 | -2.75 ± 0.96 | -17.2 ± 5.43 | 0.19 ± 0.078 */§ | -7.2 ± 3.27 |
| mon SP-B | 51.14 ± 33.47 | 1.63 ± 1.27 | -0.18 ± 0.42 | -8.0 ± 4.24 * | -11.35 ± 13.10 | 0.043 ± 0.07 | -6.0 ± 4.69 |
| nat SF | 40.78 ± 20.49 | -0.38 ± 1.71 | 0.13 ± 0.27 | -1.25 ± 3.59 | 0.3 ± 5.91 | 0.02 ± 0.06 | -3 ± 0.82 |
mean ± SD; open lung concept positive pressure ventilation (PPVOLC; n = 5); surfactant treatment under conventional positive pressure ventilation: natural bovine surfactant (Alveofact®; nat SF; n = 4), monomeric surfactant protein B based surfactant (mon SP-B; n = 4). * p < 0.05; ** p < 0.01 vs initial values (healthy; H). Further levels of significance (two-way ANOVA) are given in detail in the text.
* p < 0.05 vs nat SF
§ p < 0.05 vs mon SP-B