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. 2008 Jul 14;9:34. doi: 10.1186/1471-2172-9-34

Figure 4.

Figure 4

CpG-B also induced the production of relevant IgG autoantibodies in patients with other autoimmune diseases. PBMCs from 4 patients with autoimmune thyroiditis and 3 patients with anti-phospholipid antibody syndrome were cultured with CpG-B and IL-2. Each patient assay was paired with a healthy control. After 12 days of culture, supernatants from autoimmune thyroiditis patients were tested by ELISA for IgG anti-thyroperoxidase (TPO) as shown in A. Supernatants from anti-phospholipid antibody syndrome patients were tested for IgG anti-cardiolipin antibodies (ACLA) as shown in B.