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. 2008 Aug;132(2):251–263. doi: 10.1085/jgp.200809995

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© 2008 Campos et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 11. — Kinetic model of inactivation. (A) Kinetic diagram showing the open (O) and inactivated (I) states of the channel. Closed states are not shown and are assumed not to participate on the decay phase of the current at 0 mV (see Discussion). O₁ is invariably the first activated state. The numbers indicate the rate constants (in ms⁻¹) obtained by fitting the decay of the sodium current in the presence and absence of Ts3. In the presence of Ts3 the transitions between O₁ and O₂, and between I₁ and I₂, are blocked. (B) Experimental records in the presence and absence of Ts3 are superimposed with the theoretical curve calculated using the model and its rate constants.