TABLE I.

Voltage Dependence of the Charge Movement (Q × V) in Nav1.4 Channels Expressed in Xenopus Oocytes

Fitted parameter	Control	Ts3 200 nM	Controlb	Ts3 200 nMb
qa	0.27 ± 0.04	0.064 ± 0.007a	0.995 ± 0.006	0.69 ± 0.03a
za	2.98 ± 0.27	4.74 ± 0.60a	1.55 ± 0.12	1.47 ± 0.11
V1/2a	−71.1 ± 2.5	−78.5 ± 1.5	−44.5 ± 1.3	−40.4 ± 2.6
qb	0.71 ± 0.04	0.65 ± 0.04	0	0
zb	2.02 ± 0.29	1.87 ± 0.01	0	0
V1/2b	−34.0 ± 3.1	−42.2 ± 0.4	0	0

Values are averages of four independent experiments ± SEM. All experiments were carried out at 14°C.

^aValues statistically different from control (P < 0.05).^bSingle Boltzmann fit.