TABLE II.
Voltage Dependence of the Florescence Changes (F × V) in Mutated Nav1.4 Channels Expressed in Xenopus Oocytes
| Control
|
Ts3 200 nM
|
|||
|---|---|---|---|---|
| z | V (mV) | z | V (mV) | |
| S4DI (S216C) | 0.921 ± 0.004 | −76.7 ± 1.2 | 1.28 ± 0.11a | −57.6 ± 1.9a |
| S4DII (S660C) | 0.96 ± 0.02 | −59.8 ± 3.4 | 1.34 ± 0.07a | −60.2 ± 2.4 |
| S4DIII (L1115C) | 1.47 ± 0.07 | −70.6 ± 0.7 | 1.61 ± 0.09 | −72.1 ± 4.4 |
| S4DIV (L1439C) | 2.26 ± 0.18 | −78.2 ± 6.9 | 1.73 ± 0.09 | −59.3 ± 4.3a |
Values are averages of three independent experiments ± SEM.
a
Values statistically different from control (P < 0.05).