Table 1. Non-synonymous germline EPHB2 missense changes identified in familial and random colorectal cancer cases.

Missense Change	Residue Substitution	Exon	Domain	Familial Colorectal Cancer Cases	Random Colorectal Cancer Cases	Control Subjects
nt. 1312 G→A	A438T	6	Extracellular Fibronectin TypeIII Domain	1/116	0/364	0/384
nt. 2035 G→A	D679N	11	Protein Kinase Domain	3/116	11/1160	11/1133
nt. 2359 G→A	G787R	13	Protein Kinase Domain	1/116	0/182	0/199
nt. 2833 G→A	*V945I	15	SAM Domain	2/116	Not determined	Not determined

^*A conservative residue substitution (V945I).