Figure 10.

Comparison of Mitochondrial Fission Factors in Yeast, a Plant, and an Animal.

In yeast, a dynamin-related protein, Dnm1p, which is a mitochondrial fission executor, is recruited from the cytosol to mitochondria in a manner dependent on Fis1p and an adaptor protein, Mdv1p (and a Mdv1p-homolog, Caf4p). In the plant Arabidopsis, dynamin-related proteins, DRP3A and DRP3B, interact with ELM1 for their localization to mitochondria. Although ELM1 does not have sequence similarity to Mdv1p or Caf4p, its role may be similar to the roles of Mdv1p and Caf4p. In human, localization of dynamin-related protein, Drp1/Dlp1, to mitochondria depends on hFis1. Other proteins, such as Mdv1p, Caf4p, and ELM1, may also be involved. A black bar in Fis1 shows putative transmembrane domains. OM, outer membrane; IM, inner membrane.