Table 3.
Summary of H3 receptor-mediated cognitive effects across cognitive domains
| Compounds | Recognition memory | Spatial memory | Memory consolidation | Working memory | Executive function | Attention/impulsivity | Representative references |
|---|---|---|---|---|---|---|---|
| Histamine | |||||||
| Histamine | ↑ (SR) | ↑ (scop. def. RM) | ↑ (PA) | De Almeida and Izquierdo (1986); Prast et al. (1996); Chen (2000); Chen and Kamei (2000) | |||
| Histidine | ↑ (SR) | ↑ (scop. def. EPM) | ↑ (AA, chronic) | Kamei et al. (1993); Miyazaki et al. (1995) | |||
| H3 receptor agonists | |||||||
| Immepip | ↓ (SR) | Prast et al. (1996) | |||||
| RAMH | ↓ (OR) | ↑ (facilitated SM) | ↓ (PA) | Rubio et al. (2002) | |||
| Imetit | ↓ (OR) | ↓ (PA) | Blandina et al. (1996) | ||||
| H3 receptor antagonists | |||||||
| Thioperamide | ↑ (SR) | ↑ (scop. def. WM; no effect BM) | ↑ (PA senescence, SHR pup models) | ↑(scop. def. y-maze) | ↑ (scop. def. RM) | ↑ (SHR 5-trial IA) | Meguro et al. (1995); Miyazaki et al. (1995); Prast et al. (1996); Chen (2000); Orsetti et al. (2002); Komater et al. (2003, 2005) |
| Ciproxifan | ↑ (SR) | ↑ (BM, scop. def. WM) | ↑ (SHR 5-trial IA; 5-CSRTT) | Fox et al. (2002, 2005); Day et al. (2007) | |||
| GT-2331 | ↑ (SHR 5-trial IA) | Fox et al. (2002) | |||||
| ABT-239 | ↑ (SR, adult/aged) | ↑ (scop. def. WM) | ND | ↑ (y-maze) | ↑ (SHR 5-trial IA) | Fox et al. (2005) | |
| BF2.649 | ↑ (OR; naïve and scop. def.) | Ligneau et al. (2007b) | |||||
| JNJ-10181457 | ↑ (SHR 7-trial IA) | Bonaventure et al. (2007) | |||||
| GSK189254 | ↑ (OR) | ↑ (aged WM) | ↑ (PA) | ↑ (executive set shifting) | Medhurst et al. (2007a) | ||
Abbreviations: 5-CSRTT, five-choice serial reaction time test; AA, active avoidance; BM, Barne's maze; EPM, elevated plus maze; IA, inhibitory avoidance; OR, object recognition; PA, passive avoidance; RAMH, R-α-methyl-histamine; RM, radial maze; scop. def., scopolamine deficit; SM, spatial memory; SR, social recognition; WM, water maze.
Keys: ↑, improvement; ↓, impairment.