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. 2008 May 12;154(6):1236–1246. doi: 10.1038/bjp.2008.181

Figure 7.

Figure 7

Transmission electron micrographs of SMCs exposed to (a) 0.5% ethanol, (b) 25 μM 7-ketocholesterol, (c) 30 μM fluvastatin, (d) the combination of 7-ketocholesterol and fluvastatin, (e) 100 μM pravastatin or (f) the combination of 7-ketocholesterol and pravastatin for 18 h. Cytoplasm of SMCs exposed to 7-ketocholesterol without, or with fluvastatin or pravastatin showed intense vacuolization with vesicles containing cytoplasmic material (arrows). Magnification, × 6610; n=nucleus. (g) Immunoblot analysis of conversion of LC3-I to LC3-II in SMCs exposed to 0 or 25 μM 7-ketocholesterol without, or with 30 μM fluvastatin or 100 μM pravastatin for 18 h. LC3, microtubule-associated protein I light chain 3.